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Innovative photopatterning technology

Control the chemistry and topography of the cell  microenvironment and study their impacts on cell development using an  innovative quantitative multi-protein photopatterning solution, PRIMO

Applications

Micro-patterning

Hydrogels Polymerization

Micro-fabrication

Murine embryonic fibroblasts (MEF) with a membrane marker (Membright-Cy5) on fluorescent fibronectin

Precisely control cell adhesion to isolate them or place them in reproducible conditions for standardized assays. Several of our users’ research works show the advantages of PRIMO contactless micropatterning at single cell, cell population, and high throughput levels: 

  • Cell positioning within EM grids      for Cryo-ET (M. Toro-Nahuelpan et al., BioRxiv, 2019), 
  • Airway smooth muscle cells patterning on gel for      contraction study (S. R. Polio et al., Sci. Rep., 2019).

Micro-fabrication

Hydrogels Polymerization

Micro-fabrication

3D microstructures with a grayscale photoresist

One key advantage of PRIMO mask-less DMD-based photopatterning system is that it can perform grayscale photolithography on grayscale resists (collaboration with Physico-Chimie Curie UMR 168 and UMS-IPGG) and      therefore create complex 3D molds such as ramps, curving wells,      microfluidic chips for organ-on-a-chip applications. 

Inquire about the application note from this year’s MicroTas meeting...

Hydrogels Polymerization

Hydrogels Polymerization

Hydrogels Polymerization

4-arm-PEG-hydrogels
(blue) decorated with Poly-L-lysin(red) and fibronectin.

PRIMO can also polymerize and photo-scission most commonly used hydrogels (A. Pasturel et al., BioRxiv, 2018) for applications such as 3D cell culture within micro-niches (C. Stoecklin et al., Adv. Biosys., 2018) or permeable      hydrogel membranes polymerization within microfluidic chips (J. Decock et al., Lab. Chip, 2018).

Contact Us primo contactless micropatterning

Contact us today for additional information about our micro-patterning and micro-fabrication applications. We're here to help!

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Fairfax, VA 22030, USA

(703) 662-3276 / info@nanoscalelabs.com

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